Thursday, August 22, 2013

Concepts Well Do Adult Stem Cells Benefit OsteoArthritis of the Associated with the guitar?


Current Treatments for OsteoArthritis each knee (OAK) are erroneous. They provide symptom relief only without restore articular cartilage.

This will be excerpt from a presentation towards the American College of Rheumatology meeting using an ultrasound-guided procedure using autologous mesenchymal control cells, growth factors, so i fat matrix (GMSCL).

The forex trading hypothesis was: autologous stem cells from bone marrow while further stimulated to grow cartilage if furnished with...

• A proper scaffold
• Autologous unfold stimulating factors
• Limited weight-bearing

Our patient profile contained the following...

• 22 patients
• 36-64 years of training age
• 16 men; 6 women
• BODY MASS INDEX: 21-36. 1
• Kellgren-Lawrence power team:
o 6 grade 2
o 10 college degree 3
o 6 grade 4

In going, patients were given the following instructions...

• No NSAIDS (oral and topical) for the month prior and 4 weeks post
• No fish oil initially month prior and a month post
• May continue deterring baby aspirin
• No intraarticular injections of any kind 1 month prior or during 12 months follow up.

Our procedure is viewed as analogous to "Preparing a Garden"

• Sixty cc's marrow lessen posterior iliac crest (5 cc's remove cell concentrate~ 6 huge number of stem cells)- "seeds"
• Sixty cc's peripheral blood for creation of platelet -rich plasma (5 cc's)- "fertilizer"
• Fifteen cc's fat of one's abdomen or flank- "soil"

Ultrasound certainly advised fenestration was performed overall patients.

• Purpose: induce acute inflammatory response
• Joint capsule sites
- joints line
- adductor tubercle
- inside patellar facet

Regional Treatment on the rear of fenestrated areas and joint was therefore direct ultrasound-guided instillation of each one...

• Stem cells
• Platelet-rich plasma
• Subcutaneous fat
• Lime chloride/thrombin

Post-procedure, patients were given the following instructions...

• Non-weight-bearing for two weeks
• Limited weight-bearing with live that unloads affected compartment for four to six weeks

A summary of our results will be as follows...

Data Available

• 11 Owners at 6 months
• 10 Owners at 12 months

Treatment failures

• About four patients
• Defined as patients which have no clinical improvement after a couple of months

Two other "failures"

• Anyone died of an not related illness
• One person lived overly away to come back

Five individual consumers haven't hit the half dozen month mark

WOMAC

? 6 Months= -19. 9

SD=17. 92

SEM= 5. 67

? 12 Months= -7. 9

SD= 9. 97

SEM= 3. 15

Patient VAS Pain

? 6 Months=-33. 7

SD= sixteen. 71

SEM= 5. 57

? 12 Months= -25. 2

SD= twenty five. 94

SEM= 8. 20

Patient World - wide Assessment

? 6 Months= -33. 0

SD= twenty-four. 13

SEM= 8. 05

? 12 Months= -33. 1

SD= 19. 04

SEM= 6. 35

Patient 50 Feet Walk Pain

? 6 Months= -26. 3

SD= 15. 54

SEM= four. 91

? 12 Months= -16. 7

SD= 12. 05

SEM= four. 01

Physician Global Assessment

? 6 Months= -51. 2

SD= twenty one. 60

SEM= 6. 83

? 12 Months= -53. 0

SD= twenty-four. 15

SEM= 8. 54

Placebo end? Probably not...

Example who Celebrex vs placebo around OA trials

Mean composite WOMAC rating (pain, stiffness, physical function) = -5. 7 (-7. 5 in the -3. 9)

[Bensen WG, Fiechtner JJ, McMillen JI, Zhao WW, Yu SS, Woods EM, et al. Treatment of OsteoArthritis with celecoxib, a cyclooxygenase-2 inhibitor: a randomized controlled trial.Mayo Clin Proc 1999;74: 1095-1105; Zhao SZ, McMillen JI, Markenson JA, Dedhiya SD, Zhao WW, Osterhaus JT, et al.Evaluation of the functional status aspects of health-related quality of life of patients with OsteoArthritis treated with celecoxib. Pharmacotherapy 1999;19: 1269-1278].

Ultrasound how big of patello-femoral cartilage concentration at 7 standardized points

• Throat flexed to 90 degrees
• Similar sites matched for accuracy
• Five measurements every point for reproducibility
• High and low dropped and in what way three middle averaged

Ultrasound shape of patello-femoral cartilage look at 7 standardized points

• Mean improvement from baseline to six months (11 pts) - 0. four mm
• Mean improvement from baseline to 12 too long (10 pts) - 0. 8 mm

Conclusion

While this is an uncontrolled study, GMSCL demonstrates some promise to become Treatment for OAK. Boost study is recommended

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