Tuesday, October 22, 2013

Ask me why OsteoArthritis So Darned Difficult to Treat?

Recent research efforts their day both Northwestern University in Chicago or the University of Pittsburgh Shop have described work on who are suffering new nanofiber gel encouraging cartilage growth in bones.

The material is injected with all the damaged joint and massages bone marrow stem cells to gain natural cartilage.

The nanofibers allow control cells from bone marrow to generatte cartilage containing type II collagen and repair a displayed joint.

Type II collagen is actually major protein component inside of articular cartilage, the gristle that less difficult the ends of long bones to find a joint.

This is distinctly in comparison with the Type I collagen produced on account of another procedure used to heal cartilage damage called microfracture. Microfracture is healthcare where small holes are drilled into the bone beneath the place of cartilage damage. Leading to bleeding from the cuboid bone marrow.

Ostensibly, stem cells from the marrow create new cartilage material.

Microfracture causes the manufacture of cartilage having predominately vast array I collagen. Type I collagen is actually type found most commonly in scarring.

Type II collagen has already been weaker than Type I collagen and in all probability does not hold up as well. This may be one the reasons microfracture surgery has produce as first thought.

Another type of tactic called autologous chondrocyte transplantation has also been used. In this tactic, cartilage is harvested from a non-weight-bearing system of the joint. The cartilage will be specially treated in a laboratory as a way for individual cartilage cells three times the. The cartilage cells are then put in the birthday gift joint under a lower flap of tissue which can sewn into place. Recovery is long having said that the cartilage produced also generally contain mostly Type WHICH I collagen.

Mosaicplasty where multiple cartilage plugs are installed in the cartilage defect has also been used. Results are captured.

Stem cell Treatment your appeal of being not to invasive and requiring less quiet time. However, controlled data is nonexistent. Supportive evidence is case studies and your low numbers.

One issue that prefers plagued researchers and clinicians alike comes with the mechanical forces present within weight-bearing joints choose to hip and knee.

When asked his opinion along at the nanofiber issue, Dr. Bill Arnold, a Chicago-based rheumatologist regarded, "This isn't the normally 'cartilage growth stimulator'... and will the last. There's no way that cartilage regrows on the top medial femoral condyle (of the knee) without having a mechanical correction accompanying the "regrowth". The shear compression forces that belong to the medial compartment are powerful... and would quickly bite any flimsy cartilage surface beginning of grow on the top condyle. "

Dr. Nathan Wei, a rheumatologist doing stem cell Treatment with the OsteoArthritis, concurs with Surge. Arnold to a really. He states, "The impact loading influence on weight-bearing joints choose to knee and hip are one thing to contend with but with the hip it is undoubtedly a added stress of rotational movement and in the knee there are fashioned gliding and rotational forces to manage as well. "

He claims though, "Animal models have revealed that stem cell procedures are impressive. And while human info is sparse, early evidence backside further investigation... I do agree that mechanical forces are dealt with through various means enhance allow stem cells during the 'take'. We are currently trying to address this issue. Our results to now are very encouraging. "


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